Apex Pharmacy

Toll Free Phone: 1-844-888-7335

The human brain is the most intricate organ of our bodies. The weight of the brain is only 2% of the total body but uses 20% of our energy. It consumes as much energy as all of the other muscles of the body combined. Incidentally, the brain gets smaller as we age - approximately  0.2% per year starting at 20 years old.  At around 24, the brain is past its prime and the cognitive motor skills slowly begin to diminish. Accordingly,  the risk of cognitive disorders such as memory loss and dementia increase with aging. Despite this inevitable decline, you can compensate for this decline by developing your own anti-aging strategies. Strategies should address all of the leading instigators of aging, i.e. chronic stress, depression, sedentary lifestyle and poor diet.

A new nasal spray, Synapsin, is a prescription only compound that comes with two major ingredients;


Nicotinamide riboside (NR) - a precursor form of vitamin B3 & Ginseng (G3)


Synapsin furnishes the nutrients to provide neuroprotection of the brain cells by improving mitochondrial functioning, cardiovascular health, and cellular metabolism.

Some tips for your brain are below;

Chronic Stress

Although Stress is a natural part of life, it can damage the synapses that exchange information between neurons, increasing the risk of dementia. Stress causes the adrenal glands to secrete cortisol which disrupts learning ability and dampens memory. If the cortisol overload in response to stress continues for a prolonged period, it may cause impaired immunity, weight gain, depression, and anxiety.  Both Vitamin B3 and Ginseng has been known to alleviate stress-related symptoms.


Emotions 

Emotions are associated with the limbic system which is located beneath the cerebral cortex.  The limbic system is responsible for how feelings and our emotional state. It also stores long term memories of past experiences. Regardless of the reason, a constant negative emotional state hinders the limbic systems ability to store information.  Nicotinamide riboside, a precursor of Vitamin B3, works as a mood stabilizer by preventing the depletion of NAD+ and reducing inflammation. 

Exercise

Regular exercise stimulates brain cells to regenerate neurons in the brain. In clinical studies with the elderly, those who exercised showed higher cognitive functioning scores than those who did not. In addition, exercise prevents other life-threatening diseases such as stroke and diabetes, both of which cause serious damage to the brain. Supplementation with Vitamin B3 and ginseng can enhance your athletic performance and make you feel more like exercising.  

Synapsin Nasal Spray

Synapsin is a prescription compound that has not been evaluated by the U.S. Food and Drug Administration, nor is intended to diagnose, treat, cure or prevent any disease. No medical claims about the supplement are made in this article.  Synapsin is commonly used in combination with methylcobalamin or hydroxocobalamin dependent on the preference of your provider. 

For more information, please call Apex Pharmacy at 1(681)207-7334 and ask to speak with the compounding department.

 
References and Recommended Reading

1. Rennie, Andrew C Chen, Haryana Dhillon, et al.  Nicotinamide and neurocognitive function
Nutritional Neuroscience Vol. 18, Iss. 5,2015.

2.Kennedy DO, Scholey AB. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 2003;75:687-700.

3. Chi Y, Sauve AA. Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):657-61.

4. Choi JY, Woo TS, Yoon SY, et al. Red Ginseng Supplementation More Effectively Alleviates Psychological than Physical Fatigue. Journal of Ginseng Research. 2011;35(3):331-338. doi:10.5142/jgr.2011.35.3.331.

5. Antidepressants may lead to a decrease in niacin and NAD in patients with poor dietary intake
Viljoen, Margaretha et al.
Medical Hypotheses, Volume 84, Issue 3, 178 - 182

6.Liu D, Gharavi R, Pitta M, Gleichmann M, Mattson MP. Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons. Neuromolecular medicine. 2009;11(1):28-42. doi:10.1007/s12017-009-8058-1.

7. Attele AS, Zhou YP, Xie JT, Wu JA, Zhang L, Dey L, Pugh W, Rue PA, Polonsky KS, Yuan CS. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 2002;51:1851-1858.

8 Lee WK, Kao ST, Liu IM, Cheng JT. Ginsenoside Rh2 is one of the active principles of Panax ginseng root to improve insulin sensitivity in fructose-rich chow-fed rats. Horm Metab Res 2007;39:347-354.

9.Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD+intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell metabolism. 2011;14(4):528-536. doi:10.1016/j.cmet.2011.08.014.

10. Garten A, Petzold S, Körner A, Imai S, Kiess W. Nampt: Linking NAD biology, metabolism, and cancer. Trends in endocrinology and metabolism: TEM. 2009;20(3):130-138. doi:10.1016/j.tem.2008.10.004.

11.Garten, Antje, et al. “Physiological and pathophysiological roles of NAMPT and NAD metabolism.” Nature Reviews Endocrinology 11.9 (2015): 535-546.

12.Brown KD, Maqsood S, Huang J-Y, et al. Activation of SIRT3 by the NAD+precursor nicotinamide riboside protects from noise-induced hearing loss. Cell metabolism. 2014;20(6):1059-1068. doi:10.1016/j.cmet.2014.11.003.

13.Han C, Someya S. Maintaining good hearing: Calorie restriction, Sirt3, and glutathione. Experimental gerontology. 2013;48(10):1091-1095. doi:10.1016/j.exger.2013.02.014.

14.Massudi H, Grant R, Braidy N, Guest J, Farnsworth B, Guillemin GJ (2012) Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue. PLoS ONE 7(7): e42357. https://doi.org/10.1371/journal.pone.0042357

SYNAPSIN